Bacterial Hosts for Natural Product Production
نویسندگان
چکیده
منابع مشابه
Engineering microbial hosts for production of bacterial natural products.
Covering up to end 2015Microbial fermentation provides an attractive alternative to chemical synthesis for the production of structurally complex natural products. In most cases, however, production titers are low and need to be improved for compound characterization and/or commercial production. Owing to advances in functional genomics and genetic engineering technologies, microbial hosts can ...
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The polyketides are a diverse group of natural products with great significance as human and veterinary pharmaceuticals. A significant barrier to the production of novel genetically engineered polyketides has been the lack of available heterologous expression systems for functional polyketide synthases (PKSs). Herein, we report the expression of an intact functional PKS in Escherichia coli and ...
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In recent years, the number of recombinant proteins used for therapeutic applications and industry has increased dramatically. Recombinant proteins are produced in many host organisms (microbial, insect, plant and mammalian cells). There are many factors to consider when choosing the optimal system for protein expression and purification including the mass, purity or solubility of the recombina...
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teria, often in response to contacting host cells or host Department of Biochemistry and Molecular Biology factors (often called “contact-mediated” secretion) (reDepartment of Microbiology and Immunology viewed by Hueck, 1998). Remarkably, type III systems University of British Columbia also transport specific virulence factors directly into Vancouver, British Columbia host cells, acting as a s...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2008
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp800045q